It's really a guessing game. I'm gonna start jetting pretty soon and everything I've read/been told is it's trial and error. My guess, based on the title of this thread, is you'll have to bump the mains up 2 sizes and probably the pilot up one size.
Don't take my word for it, that just a guess. It's where I'm gonna start with mine. I'll have pods and drag/straight pipes with baffles. But I'm a couple months away from that, at least.